Pigmented or Hemosiderotic Atypical Fibroxanthoma

Pastor-Nieto, M.A.; Kilmurray, L.G.; Requena, L.

doi:10.1016/S1578-2190(09)70070-8

Actas Dermo-Sifiliográficas

ISSN: 0001-7310

The Official publication of the Spanish Academy of Dermatology and Venereology (AEDV). Actas Dermo-Sifiliográficas, founded in 1909, is the oldest monthly medical journals published in Spain. In the year 2006 has been indexed in the Medlinedatabase, and has become a vehicle for expressing the most current Spanish medicine and modern. All articles are subjected to a rigorous process of revision in pairs, and careful editing for literary and scientific style. Together with the classic Original and Clinical Case Study sections, we also include Reviews, Case Diagnoses, and Book Reviews. Dermo-Sifiliográficas is an essential publication for anyone who needs to be current on all aspects of Spanish and world dermatology.

Actas Dermo-Sifiliográficas ha recibido Factor de Impacto (JCR) por primera vez en 2023.
Guía para autores - Envío de manuscritos

Actas Dermo-Sifiliográficas has received its first journal Impact Factor (JCR) in 2023.
Instructions for authors - Submit an article

Indexed in:

Web of Science, Emerging Sources Citation Index (WoS, Clarivate), PubMed/Medlinee, IME, Embase/Excerpta Medica, Embase, Toxline, Cab Abstracts, Cab Health, Cancerlit NIm, Serline: Biomed, Bibliomed, Pascal, Scopus , IBECS

Pigmented atypical fibroxanthoma is a rare variant of atypical fibroxanthoma and is characterized by extensive areas of hemorrhage, erythrophagocytosis, and hemosiderin accumulation in the cytoplasm of the neoplastic cells. It affects elderly individuals and presents as irregularly pigmented, dome-shaped nodules or plaques on areas of skin exposed to the sun. We present a case of pigmented atypical fibroxanthoma on the cheek of an 81-year-old man. Six years after excision of the lesion, the patient remains in complete remission, with no signs of residual tumor or metastasis. The 9 cases of pigmented atypical fibroxanthoma reported in the literature are reviewed, and the histopathological features and differential diagnosis are discussed.

Key words:

atypical fibroxanthoma

pigmented

hemosiderotic

Resumen

El fibroxantoma atípico pigmentado es una variante rara de fibroxantoma atípico caracterizada por áreas extensas de hemorragia, eritrofagocitosis y depósitos de hemosiderina en el citoplasma de las células neoplásicas. Afecta a pacientes de edad avanzada, y se manifiesta como nódulos cupuliformes o placas pigmentadas, de coloración heterogénea, en áreas de piel fotoexpuesta.Se presenta un caso de fibroxantoma atípico pigmentado de localización malar en un varón de 81 años de edad. Seis años después de la extirpación quirúrgica de la lesión, el paciente permanece en remisión completa, sin que se aprecien signos clínicos de persistencia tumoral o metástasis.Se revisan los 9 casos de fibroxantoma atípico pigmentado publicados en la literatura y se discuten las características histopatológicas y el diagnóstico diferencial de esta rara entidad.

Palabras clave:

fibroxantoma atípico

pigmentado

hemosiderótico

Full text is only aviable in PDF

References

[1.]

E. Gómez-de la Fuente, M. Sols, F. Pinedo, J.G. Álvarez-Fernández, F.J. Vicente, E. Naz, et al.

Fibroxantoma atípico. Estudio clínico-patológico de 10 casos.

Actas Dermosifiliogr, 96 (2005), pp. 153-158

Medline

[2.]

B. Mirza, D. Weedon.

Atypical fibroxanthoma: a clinicopathological study of 89 cases.

Austr J Dermatol, 46 (2005), pp. 235-238

[3.]

E. Calonje, C. Wadden, E. Wilson-Jones, C.D. Fletcher.

Spindle-cell non-pleomorphic atypical fibroxanthoma: analysis of a series and delineation of a distinctive variant.

Histopathology, 22 (1993), pp. 247-254

Medline

[4.]

L. Requena, O.P. Sangueza, E.S. Yus, V. Furió.

Clear-cell atypical fibroxanthoma: an uncommon histopathologic variant of atypical fibroxanthoma.

J Cutan Pathol, 24 (1997), pp. 176

Medline

[5.]

J.J. Ríos-Martín, M. Díaz-Delgado, D. Moreno-Ramírez, A. García-Escudero, R. González-Cámpora.

Granular cell atypical fibroxanthoma: report of two cases.

Am J Dermatopathol, 29 (2007), pp. 84-87

http://dx.doi.org/10.1097/01.dad.0000246175.73447.3a | Medline

[6.]

J.F. Val-Bernal, J. Corral, F. Fernández, C. Gómez-Bellvert.

Atypical fibroxanthoma with osteoclast-like giant cells.

Acta Derm Venereol, 74 (1994), pp. 467-470

Medline

[7.]

A.K. Bruecks, S.A. Medlicott, M.J. Trotter.

Atypical fibroxanthoma with prominent sclerosis.

J Cutan Pathol, 30 (2003), pp. 336-339

Medline

[8.]

C. Díaz-Cascajo, S. Borghi, M. Bonczkowitz.

Pigmented atypical fibroxanthoma.

Histopathology, 33 (1998), pp. 537-541

Medline

[9.]

C. Díaz-Cascajo, W. Weyers, S. Borghi.

Pigmented atypical fibroxanthoma. A tumor that may be easily mistaken for malignant melanoma.

Am J Dermatopathol, 25 (2003), pp. 1-5

Medline

[10.]

B. Zelger.

Pigmented atypical fibroxanthoma, a dermatofibroma variant?.

Am J Dermatopathol, 26 (2004), pp. 84-86

Medline

[11.]

C. Díaz-Cascajo.

Pigmented atypical fibroxanthoma: not a variant of dermatofibroma: concept that atypical fibroxanthoma is squamous cell carcinoma is a misconstruction.

Am J Dermatopathol, 26 (2004), pp. 86-87

[12.]

L. Requena, A. Aguilar, M.J. López Redondo, C. Schoendorff, E. Sánchez Yus.

Multinodular hemosiderotic dermatofibroma.

Dermatologica, 181 (1990), pp. 320-323

Medline

[13.]

O. Sangüeza, L. Requena.

Hobnail hemangioma (targetoid hemosiderotic hemangioma).

Pathology of vascular skin lesions. Clinicopathologic correlations, 1st ed., pp. 157

[14.]

T.J. Browne, C.D.M. Fletcher.

Hemosiderotic fibrolipomatous tumor (so-called hemosiderotic fibrohistiocytic lipomatous tumor): analysis of 13 new cases in support of a distinct entity.

Histopathology, 48 (2006), pp. 453-461

http://dx.doi.org/10.1111/j.1365-2559.2006.02360.x | Medline

[15.]

C. Tomasini, C. Borganelli, M. Pippione.

Targetoid hemosiderotic nevus.

Dermatology, 210 (2005), pp. 200-205

http://dx.doi.org/10.1159/000083510 | Medline

Indexed in:

Follow us:

Subscribe to our newsletter