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Vol. 102. Issue 1.
Pages 53-57 (January - February 2011)
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Vol. 102. Issue 1.
Pages 53-57 (January - February 2011)
Case report
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Metastatic Basal Cell Carcinoma in the Axilla: Reconstruction with a Lateral Pectoral Island Flap
Carcinoma basocelular metastásico en la axila: reconstrucción mediante un colgajo en isla pectoral lateral
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A. Martorell-Calatayuda,
Corresponding author
antmarto@hotmail.com

Corresponding author.
, V. Sanz-Motilvab, D. Candelasc, I. Sanchez-Carpinteroc, Y. Delgadoc, R. Ruiz-Rodríguezc
a Departamento de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain
b Departamento de Dermatología, Hospital 12 de Octubre, Madrid, Spain
c Departamento de Dermatología, Hospital Ruber, Madrid, Spain
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Abstract

Although basal cell carcinoma (BCC) is one of the most common forms of cancer worldwide, it rarely occurs in the axilla. Only 31 cases have been reported in the literature. The incidence of metastatic BCC, particularly in areas not exposed to the sun, is very low. We present a new case of axillary BCC with lymph node metastases and the results of an extensive review of cases previously reported in the literature.

BCC in the axilla is rare and metastasis is exceptional. Factors other than UV radiation probably contribute to its development. The lateral pectoral island flap was used for surgical closure. This method is useful for the reconstruction of axillary defects, obtaining excellent cosmetic and functional results. This flap should therefore be considered for the repair of large surgical defects in the axilla.

Keywords:
Basal cell carcinoma
Metastasis
Axilla
Island flap
Pectoral flap
Resumen

A pesar de que el carcinoma basocelular (CBC) es una de las formas más comunes de cáncer, esta neoplasia cutánea raramente ocurre en la axila, con sólo 31 casos recogidos en la literatura. La incidencia del CBC metastásico es excepcional, siendo aún más infrecuente en áreas no fotoexpuestas.

Se presenta un nuevo caso de CBC axilar con metástasis nodal y se realiza una revisión extensa de la literatura de aquellos casos publicados previamente. El CBC localizado en la axila es un raro evento, pero el desarrollo de metástasis es excepcional. Otros factores diferentes a la radiación ultravioleta probablemente contribuyan a su desarrollo.

El colgajo en la isla pectoral lateral fue la técnica aplicada en el cierre quirúrgico. Este resulta útil en la reconstrucción de defectos quirúrgicos axilares y obtiene excelentes resultados tanto estéticos como funcionales. Por estas razones, la realización de este colgajo debería considerarse ante importantes defectos quirúrgicos en la región axilar.

Palabras clave:
Carcinoma basocelular
Metástasis
Axila
Colgajo en isla
Colgajo pectoral
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References
[1.]
B.A. Raasch, P.G. Buettner, C. Garbe.
Basal cell carcinoma: histological classification and body-site distribution.
Br J Dermatol, 155 (2006), pp. 401-407
[2.]
R.M. Van Dam, Z. Huang, E.B. Rimm, M.A. Weinstock, D. Spiegelman, G.A. Colditz, et al.
Risk factors for basal cell carcinoma of the skin in men: results from the health professionals follow-up study.
Am J Epidemiol, 150 (1999), pp. 459
[3.]
K. Pon, M.A. Trauner, G.S. Rogers.
Axillary basal cell carcinoma.
Dermatol Surg, 27 (2001), pp. 415-416
[4.]
B.W. Lesueur, D.J. Dicaudo, S.M. Connolly.
Axillary basal cell carcinoma.
Dermatol Surg, 29 (2003), pp. 1105-1108
[5.]
S.H. Woo, I.H. Kin, S.W. Son.
Axillary basal cell carcinoma.
J Eur Acad Dermatol, 20 (2006), pp. 214-238
[6.]
E.S. Gardner, L.H. Goldberg.
Axillary basal cell carcinoma: literature survey and case report.
Dermatol Surg, 27 (2001), pp. 966-968
[7.]
J.L. Barrett, K.J. Smith, J.J. Hodge.
Immunohistochemical nuclear staining for p53, PCNA, and Ki-67 in different histologic variants of basal cell carcinoma.
J Am Acad Dermatol, 37 (1997), pp. 430-437
[8.]
A.H. Mehregan.
Aggressive basal cell epithelioma on sunlightprotected skin: report of eight cases, one with pulmonary and bone metastases.
Am J Dermatopathol, 5 (1983), pp. 221-229
[9.]
M. Heckmann, F. Zogelmeier, B. Konz.
Frequency of facial basal cell carcinoma does not correlate with site-specific UV exposure.
Arch Dermatol, 138 (2002), pp. 1494-1497
[10.]
E.R. Farmer, E.B. Helwig.
Metastatic basal cell carcinoma: a clinicopathologic study of seventeen cases.
Cancer, 46 (1980), pp. 748-757
[11.]
G.T. Nahass, A. Blauvelt, C.L. Leonardi, N.S. Penneys.
Basal cell carcinoma of the scrotum. Report of three cases and review of the literature.
J Am Acad Dermatol, 26 (1992), pp. 574-578
[12.]
A. Wadhera, M. Fazio, G. Bricca, O. Stanton.
Metastatic basal cell carcinoma: a case report and literature review. How accurate is our incidence data?.
Dermatol Online J, 12 (2006), pp. 7
[13.]
S.N. Snow, W. Sahl, J.S. Lo, F.E. Mohs, T. Warner, J.A. Dekkinga, et al.
Metastatic basal cell carcinoma. Report of five cases.
Cancer, 73 (1994), pp. 328-335
[14.]
H. Von Domarus, P.J. Stevens.
Metastatic basal cell carcinoma. Report of five cases and review of 170 cases in the literature.
J Am Acad Dermatol, 10 (1984), pp. 1043-1060
[15.]
N.W. Yii, N.S. Niranjan.
Metastatic basal cell carcinoma of the axilla: report of a case and reconstruction with an island lateral pectoral flap.
Ann Plast Surg, 45 (2000), pp. 78-82
[16.]
R. Raszewski, B. Guyuron.
Long-term survival following nodal metastases from basal cell carcinoma.
Ann Plast Surg, 24 (1990), pp. 170-175
[17.]
A.D. Soleymani, N. Scheinfeld, K. Vasil, M.A. Bechtel.
Metastatic basal cell carcinoma presenting with unilateral upper extremity edema and lymphatic spread.
J Am Acad, 59 (2008), pp. S1-S3
[18.]
E. Hodak, A. Ginzburg, M. David, M. Sandbank.
Etretinate treatment of the nevoid basal cell carcinoma syndrome. Therapeutic and chemopreventative effect.
Int J Dermatol, 26 (1987), pp. 606-609
[19.]
H.M. Goldberg, H.R. Pratt-Thomas, J.S. Marvin.
Metastatic basal cell carcinoma. Report of four cases.
Plast Reconstr Surg, 59 (1977), pp. 750-753
[20.]
F. Fantini, G. Gualdi, A. Cimitan, A. Giannetti.
Metastatic basal cell carcinoma with squamous differentiation.
Arch Dermatol, 144 (2008), pp. 1186-1188
[21.]
J. Caron, O. Dereure, D. Kerob, C. Lebbe, B. Guillot.
Metastatic basal cell carcinoma: report of two cases treated with cetuximab.
Br J Dermatol, 161 (2009), pp. 702-703
[22.]
A. Saran.
Basal cell carcinoma and the carcinogenic role of aberrant Hedgehog signaling.
Future Oncol, 6 (2010), pp. 1003-1014
[23.]
B.Z. Stanton, L.F. Peng.
Small-molecule modulators of the Sonic Hedgehog signaling pathway.
Mol Biosyst, 6 (2010), pp. 44-54
Copyright © 2011. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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