TY - JOUR T1 - Candidate allergens for inclusion in the Spanish Standard Series based on data from the Spanish Contact Dermatitis Registry JO - Actas Dermo-Sifiliográficas T2 - AU - Hernández-Fernández,C.P. AU - Mercader-García,P. AU - Silvestre Salvador,J.F. AU - Sánchez Pérez,J. AU - Fernández Redondo,V. AU - Miquel Miquel,F.J. AU - Ortiz de Frutos,F.J. AU - Gatica Ortega,M.E. AU - Mora Fernández,V. AU - Giménez Arnau,A.M. AU - Zaragoza Ninet,V. AU - González Pérez,R. AU - Sanz Sánchez,T. AU - Pastor Nieto,M.A. AU - Serra Baldrich,E. AU - Córdoba Guijarro,S. AU - Heras Mendaza,F. AU - Ruiz González,I. AU - Rodríguez Serna,M. AU - Hervella Garcés,M. AU - Gallego Descalzo,M.A. AU - García Doval,I. AU - Borrego Hernando,L. SN - 15782190 M3 - 10.1016/j.adengl.2021.07.013 DO - 10.1016/j.adengl.2021.07.013 UR - https://www.actasdermo.org/en-candidate-allergens-for-inclusion-in-articulo-S1578219021002134 AB - BackgroundStandard patch test series must be updated using objective data on allergen sensitization. The Spanish standard series was last updated in 2016 and the European series in 2019, and the inclusion of several emerging allergens needs to be evaluated. Material and methodsWe conducted a prospective, observational, multicenter study of consecutive patients from the registry of the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC) who were patch tested in 2019 and 2020 with linalool hydroperoxide, limonene hydroperoxide, 2-hydroxyethyl-methacrylate, benzisothiazolinone, octylisothiazolinone, textile dye mix (TDM), sodium metabisulfite, propolis, bronopol, Compositae mix II, diazolidinyl urea, imidazolidinyl urea, decyl glucoside, and lauryl glucoside. ResultsWe analyzed data for 4,654 patients tested with diazolidinyl urea, imidazolidinyl urea, and bronopol, and 1,890 tested with the other allergens. The values for the MOAHLFA index components were 30% for male, 18% for occupational dermatitis, 15% for atopic dermatitis, 29% for hand, 6.5% for leg, 23% for face, and 68% for age > 40 years. Sensitization rates above 1% were observed for 7 allergens: linalool hydroperoxide, 2-hydroxyethyl-methacrylate, benzisothiazolinone, limonene hydroperoxide, TDM, sodium metabisulfite, and propolis. Three allergens had a current relevance rate of over 1%: linalool hydroperoxide, 2-hydroxyethyl-methacrylat, and limonene hydroperoxide. Benzisothiazolinone and TDM had a relevance rate of between 0.9% and 1%. ConclusionsOur results indicate that 7 new allergens should be considered when extending the Spanish standard patch test series. The data from our series could be helpful for guiding the next extension of the European baseline series. ER -