TY - JOUR T1 - Janus Kinase Inhibitors in Dermatology: Part 1 — General Considerations and Applications in Vitiligo and Alopecia Areata JO - Actas Dermo-Sifiliográficas T2 - AU - Garcia-Melendo,C. AU - Cubiró,X. AU - Puig,L. SN - 15782190 M3 - 10.1016/j.adengl.2021.03.012 DO - 10.1016/j.adengl.2021.03.012 UR - https://www.actasdermo.org/en-janus-kinase-inhibitors-in-dermatology-articulo-S1578219021001499 AB - Dermatologists’ interest in the Janus-associated kinase/signal transducers and activators of transcription (JAK/STAT) pathway has been growing as evidence builds to support its key role in the pathogenesis of inflammatory skin diseases. Because certain proinflammatory cytokines use the JAK/STAT pathway for signal transduction, it has become a promising therapeutic target in diseases where selective modulation of the immune system can be useful.We aim to review current knowledge of the JAK/STAT signaling pathway and its role in immune-mediated skin diseases. In the first part of the review we cover the efficacy and safety of oral and topical JAK inhibitors in the treatment of vitiligo and alopecia areata. ER -