TY - JOUR T1 - Acral Hemorrhagic Darier Disease JO - Actas Dermo-Sifiliográficas T2 - AU - Flores-Terry,M.Á. AU - García-Arpa,M. AU - Llamas-Velasco,M. AU - Mendoza-Chaparro,C. AU - Ramos-Rodríguez,C. SN - 15782190 M3 - 10.1016/j.adengl.2017.06.003 DO - 10.1016/j.adengl.2017.06.003 UR - https://www.actasdermo.org/en-acral-hemorrhagic-darier-disease-articulo-S1578219017301907 AB - Darier disease is an autosomal-dominant inherited condition caused by mutation of a gene, which produces a protein involved in calcium channel regulation. The disease has a variety of manifestations and lacks consistent genotype–phenotype correlations. Acral hemorrhagic Darier disease causes macules, papules, vesicles and/or hemorrhagic blisters on the extremities. Other classic signs of the disease may be present in the same patient or relatives. Histopathology reveals dyskeratosis and suprabasal acantholysis with hemorrhagic lacunae. We report 3 new cases of this type of Darier disease triggered by injuries. Response to retinoid therapy was good. ER -