Journal Information
Vol. 107. Issue 9.
Pages 780 (November 2016)
Vol. 107. Issue 9.
Pages 780 (November 2016)
Images in Dermatology
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Azithromycin for the Treatment of Ciclosporin-Induced Gingival Hyperplasia
Utilidad de la azitromicina en la hiperplasia gingival inducida por ciclosporina
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J.M. Martína,b,
Corresponding author
, E. Mateoc, E. Jordáa,b
a Servicio de Dermatología, Hospital Clínico Universitario, Valencia, Spain
b Departamento de Medicina, Universidad de Valencia, Valencia, Spain
c Servicio de Medicina Interna, Hospital Universitario Dr. Peset, Valencia, Spain
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Our patient was a 33-year-old woman who had received allogenic stem cell transplant for hepatosplenic T-cell lymphoma. She was administered ciclosporin, 150mg/d, as prophylaxis for graft-versus-host disease and developed progressive gingival hyperplasia, most evident 2 months after starting treatment (Fig. 1A). She was then administered azithromycin, 500mg daily for 3 days, which produced a considerable improvement at 3 weeks (Fig. 1B).

Figure 1
(0.12MB).

Gingival hyperplasia is a known complication of treatment with ciclosporin. It occurs in approximately 30% of cases, but its pathogenesis remains unknown. The mechanism of action of azithromycin is not fully understood, but it has been suggested that the drug may have a triple action in the resolution of certain periodontal diseases, due to its antimicrobial and anti-inflammatory activity and its capacity to persist at low concentrations in the macrophages and fibroblasts of the periodontal tissues, even when administered in short-term regimens of 3 to 5 days.

In more prolonged treatments, the interaction that occurs between the 2 drugs would require ciclosporin levels to be monitored and great care to be taken in patients with alterations of cardiac repolarization.

Please cite this article as: Martín JM, Mateo E, Jordá E. Utilidad de la azitromicina en la hiperplasia gingival inducida por ciclosporina. Actas Dermosifiliogr. 2016;107:780.

Copyright © 2016. Elsevier España, S.L.U. and AEDV
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