Journal Information
Vol. 104. Issue 7.
Pages 643 (September 2013)
Share
Share
Download PDF
More article options
Vol. 104. Issue 7.
Pages 643 (September 2013)
Letter to the Editor
Full text access
Comment on: Late-Onset Acquired Generalized Lipodystrophy with Muscle Involvement
Comentario a: Lipodistrofia generalizada adquirida de inicio tardío y con afectación muscular
Visits
4508
J. P Sahoo
Corresponding author
jppgi@yahoo.com

Corresponding author.
, S.K. Kamalnathan
Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), India
This item has received
Article information
Full Text
To the Editor:

After reading the interesting case report by Llamas-Velasco et al.,1 we would like to add a comment.

The authors described a case of acquired generalized lipodystrophy (AGL) with muscle involvement. The index patient with AGL had normal muscle strength and biopsy report. The evidence of muscle involvement were the presence of high creatine kinase levels and a myopathic pattern on electromyography.

Furthermore, the patient had hypothyroidism with dyslipidemia for which she was receiving levothyroxine and fenofibrate. The authors do not mention neither the dose for these 2 drugs nor the effectiveness of the levothyroxine supplementation (the results of serum thyroid stimulating hormone level). High serum creatine kinase levels and a myopathic pattern on electromyography have been reported in patients with hypothyroidism and also in such patients when they are receiving hypolipidemic therapy (fenofibrate) even in the absence of clinical evidence of muscular involvement.2,3

References
[1]
M. Llamas-Velasco, E. Daudén, G. Martínez-Peñas, A. García-Diez.
Late-onset acquired generalized lipodystrophy with muscle involvement.
Actas Dermosifiliogr, 103 (2012), pp. 729-732
[2]
R.F. Duyff, J. Van den Bosch, D.M. Laman, B.J. van Loon, W.H. Linssen.
Neuromuscular findings in thyroid dysfunction: a prospective clinical and electrodiagnostic study.
J Neurol Neurosurg Psychiatry, 68 (2000), pp. 750-755
[3]
J. Wu, Y. Song, H. Li, J. Chen.
Rhabdomyolysis associated with fibrate therapy: review of 76 published cases and a new case report.
Eur J Clin Pharmacol, 65 (2009), pp. 1169-1174

Please cite this article as: Sahoo JP., Kamalnathan S. Comentario a: Lipodistrofia generalizada adquirida de inicio tardío y con afectación muscular. Actas Dermosifiliogr. 2012. http://dx.doi.org/10.1016/j.ad.2012.12.020

Copyright © 2012. Elsevier España, S.L. and AEDV
Idiomas
Actas Dermo-Sifiliográficas
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?