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Vol. 100. Issue 10.
Pages 895-898 (December 2009)
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Vol. 100. Issue 10.
Pages 895-898 (December 2009)
Case reports
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Photodynamic Therapy for Actinic Cheilitis
Tratamiento de Queilitis Actínicas con Terapia Fotodinámica
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6892
E. Castaño
Corresponding author
ecastano.hflr@salud.madrid.org

Correspondence: Servicio de Dermatología. Hospital de Fuenlabrada. Camino del Molino 2. 28942 Fuenlabrada, Madrid, Spain.
, A. Comunión, D. Arias, R. Miñano, A. Romero, J. Borbujo
Servicio de Dermatología, Hospital de Fuenlabrada, Fuenlabrada, Madrid, Spain
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Abstract

Actinic cheilitis is a subtype of actinic keratosis that mainly affects the lower lip and has a higher risk of malignant transformation. Its location on the labial mucosa influences the therapeutic approach. Vermilionectomy requires local or general anesthetic and is associated with a risk of an unsightly scar, and the treatment with 5-fluorouracil or imiquimod lasts for several weeks and the inflammatory reaction can be very intense. A number of authors have used photodynamic therapy as an alternative to the usual treatments. We present 3 patients with histologically confirmed actinic cheilitis treated using photodynamic therapy with methyl aminolevulinic acid as the photosensitizer and red light at 630 nm. The clinical response was good, with no recurrences after 3 to 6 months of follow-up. Our experience supports the use of photodynamic therapy as a good alternative for the treatment of actinic cheilitis.

Key words:
actinic cheilitis
treatment
photodynamic therapy
Resumen

La queilitis actínica es un subtipo de queratosis actínica que afecta fundamentalmente al labio inferior y tiene un riesgo incrementado de transformación carcinomatosa. La localización en la mucosa labial condiciona las distintas posibilidades terapéuticas. La bermellectomía obliga a realizar anestesia local o general y se asocia con un riesgo de cicatriz inestética; el tratamiento con 5-fluorouracilo o imiquimod se prolonga a lo largo de varias semanas y la reacción inflamatoria puede ser muy intensa. Varios autores han empleado la terapia fotodinámica como una alternativa a los tratamientos habituales. Presentamos a tres pacientes con queilitis actínica confirmada histológicamente que fueron tratados con terapia fotodinámica utilizando ácido metilaminolevulínico como fotosensibilizante y luz roja de 630 nm. La respuesta clínica fue buena, con ausencia de recidiva al cabo de 3 a 6 meses de seguimiento. Nuestra experiencia avala el empleo de la terapia fotodinámica como una buena alternativa terapéutica para la queilitis actínica.

Palabras clave:
queilitis actínica
tratamiento
terapia fotodinámica
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References
[1.]
A. Markopoulos, E. Albanidou-Farmaki, I. Kayavis.
Actinic cheilitis: clinical and pathologic characteristics in 65 cases.
[2.]
R.P. Zitsch, B.W. Lee, R.B. Smith.
Cervical lymph node metastases and squamous cell carcinoma of the lip.
Head Neck, 21 (1999), pp. 447-453
[3.]
R.G. Dufresne Jr, M.U. Curlin.
Actinic cheilitis: a treatment review.
Dermatol Surg, 24 (1997), pp. 490-491
[4.]
I.M. Stender, H.C. Wulf.
Photodynamic therapy with 5-aminolevulinic acid in the treatment of actinic cheilitis.
Br J Dermatol, 135 (1996), pp. 454-456
[5.]
J.C. Kennedy, R.H. Pottier, D.C. Pross.
Photodynamic therapy with endogenous protoporphyrin IX. Basic principles and present clinical experience.
J Photochem Photobiol B, 6 (1990), pp. 143-148
[6.]
R.M. Szeimies, S. Karrer, S. Radakovic-Fijan.
Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: a prospective, randomized study.
J Am Acad Dermatol, 47 (2002), pp. 258-262
[7.]
C. Berking, T. Herzinger, M.J. Flaig, M. Brenner, C. Borelli, K. Degitz.
The efficacy of photodynamic therapy in actinic cheilitis of the lower lip: a prospective study of 15 patients.
Dermatol Surg, 33 (2007), pp. 825-830
[8.]
E. Sotiriou, Z. Apalla, T. Koussidou-Erremonti, D. Ioannides.
Actinic cheilitis treated with one cycle of 5-aminolaevulinic acid-based photodynamic therapy: report of 10 cases.
Br J Dermatol, 159 (2008), pp. 261-262
[9.]
M. Kodama, D. Watanabe, Y. Akita, T. Yasuhiko, Y. Matsaumoto.
Photodynamic therapy for the treatment of actinic cheilitis.
Photodermatol Photoimmunol Photomed, 23 (2007), pp. 209-210
[10.]
A. Hauschild, S. Lischner, B. Lange-Asschenfeldt, F. Egberts.
Treatment of actinic cheilitis using photodynamic therapy with methylaminolevulinate: report of three cases.
Dermatol Surg, 31 (2005), pp. 1344-1348
[11.]
M.R. Alexiades-Armenakas, R.G. Geronemous.
Lasermediated photodynamic therapy of actinic cheilitis.
J Drugs Dermatol, 3 (2004), pp. 548-551
[12.]
M. Fernández-Guarino, I. García-Morales, A. Harto, C. Montull, B. Pérez-García, P. Jaén.
Terapia fotodinámica: nuevas indicaciones.
Actas Dermosifiliogr, 98 (2007), pp. 377-395
Copyright © 2009. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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