TY - JOUR T1 - Mucocutaneous Manifestations of Infection by Histoplasma capsulatum in HIV-Negative Immunosuppressed Patients JO - Actas Dermo-Sifiliográficas T2 - AU - Gómez-Santana,L.V. AU - Torre,A.C. AU - Hernández,B.A. AU - Volonteri,V.I. AU - Laura,B. AU - Luis-Galimberti,R. SN - 15782190 M3 - 10.1016/j.adengl.2018.03.006 DO - 10.1016/j.adengl.2018.03.006 UR - https://www.actasdermo.org/en-mucocutaneous-manifestations-infection-by-histoplasma-articulo-S1578219018300489 AB - Histoplasmosis is a systemic mycosis caused by the dimorphous fungus Histoplasma capsulatum (H. capsulatum). The fungus enters the body through the respiratory tract in the form of microconidia, which are transformed into intracellular yeast-like structures in the lungs before disseminating hematogenously. Primary infection is usually asymptomatic and self-resolving. Some patients develop severe disease with acute or chronic respiratory involvement. Immunosuppressed patients, mainly those with altered cellular immunity, may have disseminated disease with variable mucocutaneous involvement characterized by papules, nodules, gummas, or ulcers with a granulomatous base. We report the case of 3 HIV-negative patients infected by H capsulatum in whom diagnosis based on the skin lesions proved essential for early initiation of treatment. ER -