TY - JOUR T1 - Advances in the Diagnosis and Treatment of Tumor Necrosis Factor Receptor–Associated Periodic Syndrome JO - Actas Dermo-Sifiliográficas T2 - AU - Aguado-Gil,L. AU - Irarrazaval-Armendáriz,I. AU - Pretel-Irazabal,M. SN - 15782190 M3 - 10.1016/j.adengl.2012.11.020 DO - 10.1016/j.adengl.2012.11.020 UR - https://www.actasdermo.org/en-advances-in-diagnosis-treatment-tumor-articulo-S1578219013001480 AB - Tumor necrosis factor receptor–associated periodic syndrome (TRAPS) is a rare autosomal dominant disease included in the group of autoinflammatory syndromes. It is characterized by recurrent episodes of fever and inflammation in different regions of the body. The main clinical manifestations are myalgia, migratory erythematous rash, periorbital edema, and abdominal pain. The diagnosis is reached using gene analysis and prognosis depends on the appearance of amyloidosis secondary to the recurrent episodes of inflammation. Tumor necrosis factor inhibitors and corticosteroids are the most widely used treatments. In recent years, significant advances have been made in the diagnosis and treatment of TRAPS, thanks to a better understanding of its pathogenesis. Dermatologists must be aware that the skin manifestations of TRAPS are particularly important, as they are often diagnostic. ER -