Consensus Document
The Spanish Standard Patch Test Series: 2016 Update by the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC)
Actualización de la serie estándar española de pruebas alérgicas de contacto por el Grupo Español de Investigación en Dermatitis de Contacto y Alergia Cutánea (GEIDAC) para 2016
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Note the absence of whealing.</p> <p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Reproduced with permission from Jantschitsch et al.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">11</span></a></p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "O. Guergué-Díaz de Cerio, A. Barrutia-Borque, J. Gardeazabal-García" "autores" => array:3 [ 0 => array:2 [ "nombre" => "O." "apellidos" => "Guergué-Díaz de Cerio" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Barrutia-Borque" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Gardeazabal-García" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731016300278" "doi" => "10.1016/j.ad.2016.02.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016300278?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016301342?idApp=UINPBA000044" "url" => "/15782190/0000010700000007/v2_201704140340/S1578219016301342/v2_201704140340/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219016301329" "issn" => "15782190" "doi" => "10.1016/j.adengl.2016.06.001" "estado" => "S300" "fechaPublicacion" => "2016-09-01" "aid" => "1417" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "ssu" "cita" => "Actas Dermosifiliogr. 2016;107:551-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2936 "formatos" => array:3 [ "EPUB" => 52 "HTML" => 2324 "PDF" => 560 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Treatment of Warts in Children: An Update" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "551" "paginaFinal" => "558" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Actualización sobre el tratamiento de las verrugas vulgares en los niños" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1125 "Ancho" => 1500 "Tamanyo" => 307803 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Common warts of differing morphology in different parts of the body in pediatric patients. Choice of treatment will be determined by the number of lesions on the dorsum of the toe (A), the periungual location (B), and the size of the warts on the heel (C).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "P. Gerlero, Á. Hernández-Martín" "autores" => array:2 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Gerlero" ] 1 => array:2 [ "nombre" => "Á." "apellidos" => "Hernández-Martín" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731016300813" "doi" => "10.1016/j.ad.2016.04.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016300813?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016301329?idApp=UINPBA000044" "url" => "/15782190/0000010700000007/v2_201704140340/S1578219016301329/v2_201704140340/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Consensus Document</span>" "titulo" => "The Spanish Standard Patch Test Series: 2016 Update by the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC)" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "559" "paginaFinal" => "566" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Hervella-Garcés, J. García-Gavín, J.F. Silvestre-Salvador" "autores" => array:4 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Hervella-Garcés" "email" => array:1 [ 0 => "marcoshervellag@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "García-Gavín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J.F." "apellidos" => "Silvestre-Salvador" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:2 [ "colaborador" => "en representación del Grupo Español de Investigación en Dermatitis de Contacto y Alergia Cutánea (GEIDAC)" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "fn1" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Complejo Hospitalario de Navarra, Pamplona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Clínica Pérez & Gavín Dermatólogos, Vigo, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Actualización de la serie estándar española de pruebas alérgicas de contacto por el Grupo Español de Investigación en Dermatitis de Contacto y Alergia Cutánea (GEIDAC) para 2016" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Scientific societies make recommendations in their individual areas of competence, and those specialized in contact allergy go to great lengths to design their own standard series in the knowledge that it will be the most widely used series in their setting and that it contains the minimum set of allergens necessary for the routine investigation of contact allergy. After a vote taken at the 60<span class="elsevierStyleSup">th</span> meeting of the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC) held on October 23-24, 2015, the members agreed on the new composition of the Spanish standard series for 2016.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Allergic contact dermatitis is caused by sensitization to substances that are often ubiquitous in the patient's environment, although the frequency and impact of potential sensitization to a specific allergen depend to a large extent on the circumstances in which the exposure occurs, the intensity of the contact, and environment-specific characteristics. Consequently, the frequency of sensitization to a specific allergen often differs considerably between neighboring countries or regions. Rates of sensitization reported in hospitals are often markedly affected by socioeconomic characteristics, geography, and climate. The most frequently detected allergens (preservatives, metals, perfumes, paraphenylenediamine, and rubber additives) are common to all of our neighboring countries. However, occasionally striking differences are found. In Spain, for example, allergy to leather shoes is still very common, mainly owing to considerable exposure and increased release of chrome to the skin as a result of heat and sweating in summer,<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">1</span></a> as is the extremely high frequency of sensitization to nickel.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The standard or baseline series is a minimum set of allergens included in the basic workup applied to all patients who attend a contact allergy clinic. It includes the most frequent allergens in the environment, and each scientific society proposes its own. For practical reasons, most recommended standard series contain around 30 allergens.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Standard series are renewed regularly, according to—as might be expected—regional variations in the frequency of sensitization. It therefore seems natural that the Spanish series is not a copy of series from other countries and that it is modified over time. Despite the availability of a standard European series recommended by the European Contact Dermatitis Research Group (ECDRG), within the European Society of Contact Dermatitis (ESCD), the position of the Spanish group is that of maintaining our own criteria in the choice of standard allergens. Consequently, our series differs from the European series in some aspects. The last European standard series was modified in 2014,<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">3</span></a> and a proposal has been made to include a new allergen.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">4</span></a> It contains 30 allergens, 26 of which are in the Spanish series. The latest approved Spanish standard series comprises 32 allergens. It came into force in 2016 and replaces the last series, which was revised in 2012.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">5</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Epidemiology of Contact Dermatitis in Spain</span><p id="par0025" class="elsevierStylePara elsevierViewall">Epidemiological changes take place year after year, although exhaustive epidemiological studies showing the exact figures for sensitization in Spain are lacking. The last national study to collect data on allergic sensitization to standard allergens was published in 2004.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Several members of GEIDAC recently joined a European initiative, the European Surveillance System on Contact Allergies (ESSCA),<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">7</span></a> which was formed as an ESCD working group, and founded the Spanish Network for Surveillance of Contact Allergy (REVAC). The network brings together sensitization data that each center reports to a national database and thus helps to determine the frequency and importance of various allergens in Spain (data are subsequently sent to the European network). The network can act as a sentinel, since by analyzing annual figures it can detect variations in the frequency of sensitization and the emergence of new allergens. Some of the results of the work carried out by REVAC have already been published.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In 2012, GEIDAC participated in an epidemiological study that included 3466 patients who underwent patch testing in 17 centers throughout Spain and whose results were subsequently presented at the 12<span class="elsevierStyleSup">th</span> congress of the European Society of Contact Dermatitis in 2014.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">8</span></a> The study population included all consecutive patients who underwent patch testing at each center during the natural year; the frequencies of sensitization to each standard allergen and its relevance are set out in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. Interestingly, the study revealed that the 15 most prevalent allergens accounted for 85.3% of all positive test results, 82.7% of positive results with present relevance, and 92.5% of positive results with past relevance. The main allergens were nickel, which continues to be the most frequent of all, isothiazolinone mix, which has doubled in frequency, and fragrance mix II, which, despite being a “recent” allergen in the standard series, is the sixth most important allergen based on positive results with present relevance. Also noteworthy among the most common allergens in the study, albeit in a negative sense, were thiomersal and mercury, since, even though they often elicited reactions, less than 10% had present relevance. The allergens with the lowest rates of sensitization were primin and clioquinol. We can therefore deduce that it would be of little practical value to recommend a standard series of more than 30 allergens, since it would greatly increase workload with no appreciable improvement in detection capacity.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Members of GEIDAC have performed other multicenter studies on specific allergens from the standard series or on allergens that are candidates for the standard series,<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">9–11</span></a> and several studies are ongoing.</p><p id="par0045" class="elsevierStylePara elsevierViewall">In addition to data from multicenter studies or national studies on the frequency of sensitization to patch test allergens, members of GEIDAC have their own databases, which were often the fruit of careful annual recording of the results of the work carried out in their units and clinics. This very valuable information, some of which has been published,<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">12</span></a> enables professionals to have their own highly qualified criteria with respect to the frequency and importance of the allergens in their setting.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Methods. How Was the Standard Series Chosen?</span><p id="par0050" class="elsevierStylePara elsevierViewall">During a scientific session at the latest GEIDAC meeting, participants presented and discussed the epidemiologic data analyzed by REVAC between 2008 and 2014, as well as several relevant epidemiological studies on allergy to rubbers, corticosteroids, nickel, methylisothiazolinone, and occupational allergens. This session was followed by a specific session dedicated to updating the Spanish standard series.</p><p id="par0055" class="elsevierStylePara elsevierViewall">The meeting was attended by 26 of the 28 members of GEIDAC, and a voting system was established to maintain each hapten in the standard series or to exclude it. The members agreed that at least a solid majority would be necessary (two-thirds of the votes) to make changes with respect to the allergen. Participants were given the opportunity to defend conflicting opinions when doubts arose. The vote was then repeated, and a majority of half plus one (absolute majority) was considered valid for accepting the change proposed.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Consensus was very broad, and agreement was unanimous for almost all the allergens. A second round of voting was necessary for ethylenediamine, paraben mix, carbamate mix, methyldibromo glutaronitrile, and phenoxyethanol, which were finally maintained. A second vote was also necessary for 4 haptens that were conclusively eliminated from the series with a wide majority (more than two-thirds), namely, clioquinol, thiomersal, mercury, and primin.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Of note, allergens that were relatively uncommon according to the statistics of GEIDAC were maintained by general approval. These included epoxy resin, which is relevant in the workplace, and markers of sensitization to topical corticosteroids (tixocortol and budesonide), which are important and not usually suspected by physicians.</p><p id="par0070" class="elsevierStylePara elsevierViewall">The most controversial allergens were as follows: carbamate mix, which is problematic (frequent irritant, doubtful, or weak reactions) and was eliminated from the European series; ethylenediamine, which was eliminated from the European series and has fallen into disuse, although it is still found in some topical medicines that are widely used in Spain (eg, Positon cream); and methyldibromo glutaronitrile, which has been prohibited in cosmetics<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">13</span></a> since 2007, but which may still be present in the workplace. The prevalence of contact allergy to parabens and phenoxyethanol is very low. Phenoxyethanol in particular was the subject of intense debate, although eventually it was decided to maintain both allergens in the standard series, since they are the most commonly used preservatives in cosmetics (phenoxyethanol will be reevaluated in future updates, depending on its frequency of sensitization).</p><p id="par0075" class="elsevierStylePara elsevierViewall">GEIDAC has undertaken to review the standard series every 2 years with the aim of adapting it to future needs and changes.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">The 2016 Spanish Standard Series</span><p id="par0080" class="elsevierStylePara elsevierViewall">The modifications agreed upon affect the 2012 standard series. The recommendations set out herein came into force at the beginning of the year 2016, and GEIDAC recommends they be used from now onward. The updated series is shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">The main changes are as follows:</p><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Elimination of 4 Haptens</span><p id="par0090" class="elsevierStylePara elsevierViewall">Clioquinol: Clioquinol was eliminated because of its low frequency of sensitization (1 per 1000 patients who undergo patch testing), its uncommon clinical relevance, and the fact that it has fallen into disuse as a fungicide and amebicide, even though it is a traditional allergen that is still present in the European standard series.</p><p id="par0095" class="elsevierStylePara elsevierViewall">Thiomersal and mercury: Thiomersal and mercury were eliminated owing to obsolescence, because mercury was prohibited in Europe in 2005 (mercury-based antiseptics including thiomersal are restricted to concentrations of <<span class="elsevierStyleHsp" style=""></span>0.007% of total mercury and are only found in eye makeup and makeup remover).<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">14–16</span></a> Sensitization to these classic haptens in the patch tests was very frequent (3%-4% of patients tested), although without clinical relevance in the vast majority of cases. Mercury and thiomersal were not in the European standard series, but they were maintained in the Spanish series because of their historical relevance: mercury is used in dental amalgams, contact allergy to merbromin was frequent in the past, and systemic contact dermatitis due to inhalation of mercury from broken thermometers was occasionally detected, although this is increasingly unlikely today, since the ban on the use of mercury came into force in the European Union in 2007.<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">15</span></a> Thiomersal was often used in the past as a preservative in vaccines and antitoxins and as an antiseptic in contact lens fluid and eye cosmetics. However, sensitization to thiomersal is rarely the cause of symptoms today, and its involvement has been relegated to potential cross-reactivity with piroxicam owing to its thiol group.</p><p id="par0100" class="elsevierStylePara elsevierViewall">Primin, or 2-methoxy-6-n-pentyl-parabenzoquinone: Primin is the main allergen from the plant <span class="elsevierStyleItalic">Primula obconica</span> and is relatively common in the Baltic states and Benelux. However, it is extremely uncommon in Spain, with such a low prevalence among patients undergoing patch testing that its presence in the standard series is no longer justified. This is because of the reduced availability of and exposure to the sensitizing plant in Spain.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Other Modifications</span><p id="par0105" class="elsevierStylePara elsevierViewall">Caine mix 7% in petrolatum (pet) is the only allergen that has been accepted as a marker of allergy to ester-type local anesthetic drugs (para-aminobenzoate group). The previous series allowed patch testing both with benzocaine mix and with benzocaine 5% pet alone, although this is no longer accepted.</p><p id="par0110" class="elsevierStylePara elsevierViewall">The test concentrations of 2 major classic allergens have also been modified in the new standard series, as follows:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0115" class="elsevierStylePara elsevierViewall">Methylchloroisothiazolinone/methylisothiazolinone (Kathon CG): the concentration has increased from 100 to 200<span class="elsevierStyleHsp" style=""></span>ppm in aqueous solution (aq) (200<span class="elsevierStyleHsp" style=""></span>ppm [0.02%] aq, which is equivalent to 0.006<span class="elsevierStyleHsp" style=""></span>mg/cm<span class="elsevierStyleSup">2</span>), in accordance with the latest scientific evidence.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">3</span></a></p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0120" class="elsevierStylePara elsevierViewall">Formaldehyde: the concentration has increased from 1% to 2% aq (from 0.30 to 0.60<span class="elsevierStyleHsp" style=""></span>mg/cm<span class="elsevierStyleSup">2</span>), as recommended by Ponten et al.<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">17</span></a> in 2013 on behalf of the ESCD.</p></li></ul></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">New Haptens</span><p id="par0125" class="elsevierStylePara elsevierViewall">The new standard series includes 3 new haptens:</p><p id="par0130" class="elsevierStylePara elsevierViewall">Methylisothiazolinone, which is recommended for patch testing at a concentration of 2000<span class="elsevierStyleHsp" style=""></span>ppm aq (2000<span class="elsevierStyleHsp" style=""></span>ppm [0.2%] aq),<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">18</span></a> has been the main emergent allergen in contact allergy clinics in recent years. The frequency of sensitization in our study was 5% (although the allergen was tested at a lower concentration than currently recommended; see <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). In most centers today, we see a positive test result in 1 of every 8-10 patients who undergo patch testing, often independently of the classic mix of methylchloroisothiazolinone/methylisothiazolinone (ie, a positive reaction to methylisothiazolinone only and not to the mix). Furthermore, to date, a high percentage of present relevance has been observed with this allergen. The geometric growth in the number of cases of allergy to this preservative is undoubtedly due to the authorization of its use at concentrations of up to 100<span class="elsevierStyleHsp" style=""></span>ppm in cosmetics in the European Union.<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">19,20</span></a> Unless the situation of methylisothiazolinone allergen is resolved soon through regulation, the allergen will continue to be one of the main causes of contact allergy in the future.<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">21</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Diazodinyl urea 2% pet and imidazolidinyl urea 2% pet are both formaldehyde-releasing preservatives that have become increasingly used in cosmetics and topical drugs during the last 10 years. The frequency of sensitization to these drugs in Spain is around 0.5% to 1% of all patients undergoing patch tests,<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">8,11</span></a> which is similar to frequencies reported in the rest of Europe but lower than that reported in the United States of America.<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">22</span></a> The importance of these findings lies in the fact that patients who are allergic to these preservatives often do not test positive to formaldehyde alone; therefore, the preservative is of no use as a marker in screening for allergies to its releasers.</p><p id="par0140" class="elsevierStylePara elsevierViewall">The main suppliers of patches and patch tests in Spain—Chemotechnique, Vellinge (Sweden), and Martí Tor Alergia, Barcelona (Spain)—have been notified of our recommendations and are now marketing the GEIDAC 2016 standard series presented here.</p><p id="par0145" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#sec0065">Appendix B</a> (see supplementary material) clarifies various aspects of the allergens and mixes, as well as the differences in some marketed allergens.</p></span></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">What to test when TRUE test is used?</span><p id="par0150" class="elsevierStylePara elsevierViewall">The prepared allergen system known as the Thin-layer Rapid Use Epicutaneous Patch Test (TRUE test, SmartPractice) does not coincide exactly with either the European or the Spanish standard series. The main differences between the TRUE test and the Spanish standard series are as follows<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">23</span></a>:<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0155" class="elsevierStylePara elsevierViewall">The TRUE-TEST lacks 5 allergens: methylisothiazolinone, sesquiterpene lactone mix, fragrance mix II, lyral, and phenoxyethanol; therefore, dermatologists who use this test in their daily practice will have to test the 5 individual allergens separately.</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0160" class="elsevierStylePara elsevierViewall">The concentration of some allergens is lower and does not meet recommendations. This is particularly important in the case of methylchloroisothiazolinone/methylisothiazolinone (0.004<span class="elsevierStyleHsp" style=""></span>mg/cm<span class="elsevierStyleSup">2</span>) and formaldehyde (0.18<span class="elsevierStyleHsp" style=""></span>mg/cm<span class="elsevierStyleSup">2</span>)</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">-</span><p id="par0165" class="elsevierStylePara elsevierViewall">The patch with N-isopropyl-N-phenyl-paraphenylenediamine also includes black rubber mix. The paraben mix includes a fifth paraben (benzylparaben). The mercapto mix contains 3 components, not 4.</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">-</span><p id="par0170" class="elsevierStylePara elsevierViewall">The TRUE test includes 8 allergens that are no longer included in the Spanish standard series: thiomersal, quinoline, gold sodium thiosulfate, hydrocortisone-17-butyrate, bacitracin, parthenolide, disperse blue 106, and bronopol.</p></li></ul></p><p id="par0175" class="elsevierStylePara elsevierViewall">Since there is no clear evidence to support the traditional testing system (syringes and Finn chambers) over the TRUE test or evidence to the contrary,<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">24,25</span></a> the choice of one or the other is based on personal criteria and on the experience of the dermatologist.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">How Can the Dermatologist Benefit From the Standard Series?</span><p id="par0180" class="elsevierStylePara elsevierViewall">Data show that, in all countries, the standard series enables the detection a variable yet very substantial percentage of contact allergies, even in highly specialized units.<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">26</span></a> Therefore, testing with a standard series should be the common minimum requirement in workups for confirmation of a reasonable suspicion of contact allergy and should offer a guarantee to the dermatologist who uses it that the initial study is relatively complete.</p><p id="par0185" class="elsevierStylePara elsevierViewall">The standard series is not exhaustive, although it does contain mixes and a very varied sample of haptens, thus making it possible to test patients with the chemical structures that most commonly cause sensitization (electrophilic metals, short-chain alcohols and aldehydes, amines, peroxides, terpenes, and radical groups in alfa beta unsaturated rings) and that are therefore present in the most common contact allergens. All of the experts agree that it should be the starting point of any study. Of course, it can never replace other tests, which will always be performed based on clinical suspicion, history, and occupational or domestic exposure.<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">27</span></a> The patient's own products are particularly important and play a key role in diagnosis, although appropriate application often requires experience and sound judgment.<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">28</span></a></p><p id="par0190" class="elsevierStylePara elsevierViewall">Experience and good sense will sometimes lead the dermatologist to refer the patient to a reference clinic, especially when further tests are complex or unavailable and when the case is particularly severe or has an unusual presentation or when the patient's condition does not improve after the initial basic workup.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Future Perspectives</span><p id="par0195" class="elsevierStylePara elsevierViewall">GEIDAC is currently participating in several international studies on contact allergy to fragrances, hydroperoxides, and textile dyes and in a Spanish study on allergy to corticosteroids.</p><p id="par0200" class="elsevierStylePara elsevierViewall">GEIDAC has undertaken to step up its involvement in multicenter studies and to continue to play an active part in epidemiological surveillance in Spain. In the coming years, GEIDAC also aims to integrate data collected annually by all its members into a national database, which will lend consistency to future epidemiological studies by GEIDAC and make it possible to detect trends among emerging allergens. This valuable information will in turn provide better criteria that can help to perfect and update the Spanish standard series so that dermatologists can apply it in their own in daily practice.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflicts of Interest</span><p id="par0205" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:3 [ "identificador" => "xres828130" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec824360" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres828131" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec824361" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Epidemiology of Contact Dermatitis in Spain" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Methods. How Was the Standard Series Chosen?" ] 7 => array:3 [ "identificador" => "sec0020" "titulo" => "The 2016 Spanish Standard Series" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0025" "titulo" => "Elimination of 4 Haptens" ] 1 => array:2 [ "identificador" => "sec0030" "titulo" => "Other Modifications" ] 2 => array:2 [ "identificador" => "sec0035" "titulo" => "New Haptens" ] ] ] 8 => array:2 [ "identificador" => "sec0075" "titulo" => "What to test when TRUE test is used?" ] 9 => array:2 [ "identificador" => "sec0045" "titulo" => "How Can the Dermatologist Benefit From the Standard Series?" ] 10 => array:2 [ "identificador" => "sec0050" "titulo" => "Future Perspectives" ] 11 => array:2 [ "identificador" => "sec0055" "titulo" => "Conflicts of Interest" ] 12 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec824360" "palabras" => array:6 [ 0 => "Epidemiology" 1 => "Allergic contact dermatitis" 2 => "Type IV hypersensitivity" 3 => "Skin tests" 4 => "Patch tests" 5 => "Hapten" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec824361" "palabras" => array:6 [ 0 => "Epidemiología" 1 => "Dermatitis de contacto alérgica" 2 => "Hipersensibilidad tipo <span class="elsevierStyleSmallCaps">IV</span>" 3 => "Pruebas cutáneas" 4 => "Pruebas del parche" 5 => "Hapteno" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The Spanish standard patch test series, as recommended by the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC), has been updated for 2016. The new series replaces the 2012 version and contains the minimum set of allergens recommended for routine investigation of contact allergy in Spain from 2016 onwards.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Four haptens —clioquinol, thimerosal, mercury, and primin—have been eliminated owing to a low frequency of relevant allergic reactions, while 3 new allergens —methylisothiazolinone, diazolidinyl urea, and imidazolidinyl urea—have been added. GEIDAC has also modified the recommended aqueous solution concentrations for the 2 classic, major haptens methylchloroisothiazolinone/methylisothiazolinone mix, which is now to be tested at 200<span class="elsevierStyleHsp" style=""></span>ppm in aqueous solution, and formaldehyde, which is now to be tested in a 2% aqueous solution.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Updating the Spanish standard series is one of the functions of GEIDAC, which is responsible for ensuring that the standard series is suited to the country's epidemiological profile and pattern of contact sensitization.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La serie estándar española de pruebas alérgicas de contacto recomendada por el Grupo Español de Investigación en Dermatitis de Contacto (GEIDAC) ha sido actualizada para 2016. La nueva serie sustituye a la que estaba vigente desde 2012, y el Grupo la recomienda utilizar a partir de ahora como herramienta básica de la consulta de eccema de contacto.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La nueva serie estándar elimina, por la falta de frecuencia de positividades relevantes, 4 haptenos: clioquinol, tiomersal, mercurio y primina, y añade 3 nuevos: metilisotiazolinona, diazolidinil urea e imidazolidinil urea. Modifica además la concentración en agua de 2 haptenos clásicos muy importantes: la mezcla metilcloroisotiazolinona/metilisotiazolinona, que pasa a 200<span class="elsevierStyleHsp" style=""></span>ppm aq, y el formaldehído, que se parcheará a partir de ahora al 2% aq.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La actualización de la serie estándar española es una de las funciones del GEIDAC, que vela por su adecuación a la epidemiología y la casuística de nuestro entorno.</p></span>" ] ] "NotaPie" => array:2 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Los miembros del Grupo Español de Investigación en Dermatitis de Contacto y Alergia Cutánea (GEIDAC) se presentan en el <a class="elsevierStyleCrossRef" href="#sec0060">Anexo A</a>.</p>" "identificador" => "fn1" ] 1 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as: Hervella-Garcés M, García-Gavín J, Silvestre-Salvador JF, en representación del Grupo Español de Investigación en Dermatitis de Contacto y Alergia Cutánea (GEIDAC). Actualización de la serie estándar española de pruebas alérgicas de contacto por el Grupo Español de Investigación en Dermatitis de Contacto y Alergia Cutánea (GEIDAC) para 2016. Actas Dermosifiliogr. 2016;107:559–566.</p>" ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:2 [ 0 => array:4 [ "apendice" => "<p id="par0210" class="elsevierStylePara elsevierViewall">M. Hervella-Garcés. Servicio de Dermatología, Complejo Hospitalario de Navarra, Pamplona.</p> <p id="par0215" class="elsevierStylePara elsevierViewall">J. García-Gavín. Clínica Pérez & Gavín Dermatólogos, Vigo.</p> <p id="par0220" class="elsevierStylePara elsevierViewall">J.C. Armario-Hita. Servicio de Dermatología, Hospital Universitario de Puerto Real, Cádiz.</p> <p id="par0225" class="elsevierStylePara elsevierViewall">L. Borrego-Hernando. Servicio de Dermatología, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria.</p> <p id="par0230" class="elsevierStylePara elsevierViewall">J.M. Carrascosa-Carrillo. Servicio de Dermatología, Hospital Universitari Germans Trias i Pujol, Badalona.</p> <p id="par0235" class="elsevierStylePara elsevierViewall">S. Córdoba-Guijarro. Servicio de Dermatología, Hospital Universitario de Fuenlabrada, Madrid.</p> <p id="par0240" class="elsevierStylePara elsevierViewall">V. Fernández-Redondo. Servicio de Dermatología, Complejo Hospitalario Universitario de Santiago de Compostela.</p> <p id="par0245" class="elsevierStylePara elsevierViewall">B. García-Bravo. Departamento de Dermatología, Hospital Virgen Macarena, Sevilla.</p> <p id="par0250" class="elsevierStylePara elsevierViewall">M.E. Gatica-Ortega. Servicio de Dermatología, Hospital Virgen de la Salud, Toledo.</p> <p id="par0255" class="elsevierStylePara elsevierViewall">A. Giménez-Arnau. Servicio de Dermatología, Hospital del Mar-Parc de Salut Mar, Barcelona.</p> <p id="par0260" class="elsevierStylePara elsevierViewall">E. Giménez-Arnau. Dermatochemistry Laboratory, University of Strasbourg-CNRS, Estrasburgo, Francia.</p> <p id="par0265" class="elsevierStylePara elsevierViewall">E. Gómez-de la Fuente. Servicio de Dermatología, Hospital Universitario Fundación Alcorcón, Madrid.</p> <p id="par0270" class="elsevierStylePara elsevierViewall">R. González-Pérez. Servicio de Dermatología, Hospital Universitario de Araba, Vitoria-Gasteiz.</p> <p id="par0275" class="elsevierStylePara elsevierViewall">D. Guimaraens-Juanena. Dermatóloga, Madrid.</p> <p id="par0280" class="elsevierStylePara elsevierViewall">F. Heras-Mendaza. Servicio Dermatología, Hospital Fundación Jiménez Díaz, Madrid.</p> <p id="par0285" class="elsevierStylePara elsevierViewall">P. Manrique-Martínez. Servicio de Dermatología, Hospital Galdakao, Bilbao.</p> <p id="par0290" class="elsevierStylePara elsevierViewall">P. Mercader-García. Servicio de Dermatología, Hospital General Universitario Morales Meseguer, Murcia.</p> <p id="par0295" class="elsevierStylePara elsevierViewall">A. Miranda-Romero. Servicio de Dermatología, Hospital Clínico Universitario de Valladolid.</p> <p id="par0300" class="elsevierStylePara elsevierViewall">F.J. Ortiz-de Frutos. Servicio de Dermatología, Hospital Universitario 12 de Octubre, Madrid.</p> <p id="par0305" class="elsevierStylePara elsevierViewall">M.A. Pastor-Nieto. Servicio de Dermatología, Hospital Universitario de Guadalajara.</p> <p id="par0310" class="elsevierStylePara elsevierViewall">M. Rodríguez-Serna. Servicio de Dermatología, Hospital Universitario La Fe, Valencia.</p> <p id="par0315" class="elsevierStylePara elsevierViewall">I. Ruiz-González. Servicio de Dermatología, Complejo Asistencial Universitario de León.</p> <p id="par0320" class="elsevierStylePara elsevierViewall">P. Sánchez-Pedreño. Servicio de Dermatología, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia.</p> <p id="par0325" class="elsevierStylePara elsevierViewall">J. Sánchez-Pérez. Servicio de Dermatología, Hospital Universitario de la Princesa, Madrid.</p> <p id="par0330" class="elsevierStylePara elsevierViewall">T. Sanz-Sánchez. Servicio de Dermatología, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid.</p> <p id="par0335" class="elsevierStylePara elsevierViewall">E. Serra-Baldrich. Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona</p> <p id="par0340" class="elsevierStylePara elsevierViewall">J. Vilaplana-Vilaplana. Dermatólogo. Tarragona.</p> <p id="par0345" class="elsevierStylePara elsevierViewall">J.F. Silvestre-Salvador. Servicio de Dermatologia, Hospital General Universitario de Alicante.</p>" "etiqueta" => "Anexo" "titulo" => "List of the members of Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC)" "identificador" => "sec0060" ] 1 => array:4 [ "apendice" => "<p id="par0355" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>" "etiqueta" => "Appendix B" "titulo" => "Supplementary data" "identificador" => "sec0070" ] ] ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Abbreviations: aq, aqueous solution; GEIDAC, Spanish Contact Dermatitis and Skin Allergy Research Group; IPPD, N-isopropyl-N-phenyl–paraphenylenediamine; pet, petrolatum.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tested, No. \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Positive, No. \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Positive, % \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Present Relevance, % \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Past Relevance, % \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Relevance Unknown, % \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Nickel sulfate 5% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">877 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25.30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Methylchloroisothiazolinone 100</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">ppm (0.01%) aq</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">290 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8.37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Cobalt chloride 1% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">185 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Potassium dichromate 0.5% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">172 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.96 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">64 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Paraphenylenediamine 1% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">156 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">66 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Fragrance mix I 8% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">152 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">72 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Thiomersal 0.1% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">151 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">72 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Mercury 0.5% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">104 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">53 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Fragrance mix II 14% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3418 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">98 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.87 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">76 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Balsam of Peru 25% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">87 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">64 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Carba mix 3% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Methyldibromo glutaronitrile 0.5% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3151 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">66 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">51 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Thiuram mix 1% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">77 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Caine mix 7% pet (or benzocaine 5% pet)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">38 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">p-tert Butylphenol formaldehyde resin 1% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.47 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Colophony 20% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">54 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Formaldehyde 1% aq</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">65 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Lyral 5% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3418 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">74 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Epoxy resin 1% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Quaternium 15 (Dowicil 200) 1% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">68 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Ethylenediamine dihydrochloride 1% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.89 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Neomycin sulfate 20% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.87 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Phenyl IPPD 0.1% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">38 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Wool alcohols 30% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Mercapto mix 2% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">80 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Tixocortol-21-pivalate 0.1% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Budesonide 0.01% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Sesquiterpene lactone mix 0.1% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Mercaptobenzothiazole 2% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">84 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Phenoxyethanol 1% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3098 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Paraben mix 16% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">67 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Primin 0.01% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3409 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Clioquinol 5% pet</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">67 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="7" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="7" align="left" valign="top"><span class="elsevierStyleItalic">(Allergens that are candidates for the standard series)</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Methylisothiazolinone 500<span class="elsevierStyleHsp" style=""></span>ppm aq \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3218 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">168 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">92 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Diazolidinyl urea 2% pet \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3218 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Imidazolidinyl urea 2% pet \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3218 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.47 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">86 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1393365.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Data on the frequency and percentage of present, past, and unknown relevance for the 33 allergens from the 2012 standard series and a further 3 candidate allergens.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Results of the GEIDAC 2012 Epidemiological Study<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a></p>" ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Abbreviations: aq, aqueous solution; GEIDAC, Spanish Contact Dermatitis and Skin Allergy Research Group; pet, petrolatum.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Nickel sulfate 5% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Wool alcohols 30% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Neomycin sulfate 20% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">4. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Potassium dichromate 0.5% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">5. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Caine mix 7% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Fragrance mix <span class="elsevierStyleSmallCaps">I</span> 8% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">7. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Colophony 20% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">8. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Epoxy resin, bisphenol A 1% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">9. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Methylisothiazolinone 0.2% aq (2000<span class="elsevierStyleHsp" style=""></span>ppm) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">10. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Balsam of Peru 25% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">11. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Ethylenediamine dihydrochloride 1% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">12. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cobalt chloride 1% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">13. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">p-tert</span> Butylphenol formaldehyde resin 1% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">14. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Parabens mix 16% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">15. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Carba mix 3% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">16. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N-Isopropyl-N-phenyl–paraphenylenediamine 0.1% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">17. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Methylchloroisothiazolinone/methylisothiazolinone 0.02% aq (200<span class="elsevierStyleHsp" style=""></span>ppm) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">18. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Quaternium 15 1% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">19. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Mercaptobenzothiazole 2% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">20. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Paraphenylenediamine 1% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">21. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Formaldehyde 2% aq \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">22. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Mercapto mix 2% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">23. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Imidazolidinyl urea 2% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">24. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Thiuram mix 1% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">25. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Diazolidinyl urea 2% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">26. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Sesquiterpene lactone mix 0.1% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">27. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Tixocortol-21-pivalate 0.1% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">28. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Budesonide 0.01% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">29. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Methyldibromo glutaronitrile 0.5% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">30. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Fragrance mix <span class="elsevierStyleSmallCaps">II</span> 14% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">31. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lyral 5% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">32. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2-Phenoxyethanol 1% pet \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1393364.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">GEIDAC Standard Series 2016.</p>" ] ] 2 => array:5 [ "identificador" => "upi0005" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "Ecomponente" => array:2 [ "fichero" => "mmc1.docx" "ficheroTamanyo" => 15020 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:29 [ 0 => array:3 [ "identificador" => "bib0150" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiología del eccema de contacto en España. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 179 | 54 | 233 |
| 2024 September | 144 | 38 | 182 |
| 2024 August | 155 | 57 | 212 |
| 2024 July | 167 | 29 | 196 |
| 2024 June | 131 | 38 | 169 |
| 2024 May | 129 | 37 | 166 |
| 2024 April | 127 | 35 | 162 |
| 2024 March | 122 | 29 | 151 |
| 2024 February | 104 | 36 | 140 |
| 2024 January | 119 | 42 | 161 |
| 2023 December | 70 | 16 | 86 |
| 2023 November | 94 | 38 | 132 |
| 2023 October | 90 | 19 | 109 |
| 2023 September | 82 | 44 | 126 |
| 2023 August | 60 | 24 | 84 |
| 2023 July | 95 | 36 | 131 |
| 2023 June | 92 | 28 | 120 |
| 2023 May | 103 | 29 | 132 |
| 2023 April | 72 | 26 | 98 |
| 2023 March | 128 | 25 | 153 |
| 2023 February | 134 | 30 | 164 |
| 2023 January | 64 | 29 | 93 |
| 2022 December | 90 | 45 | 135 |
| 2022 November | 60 | 38 | 98 |
| 2022 October | 65 | 26 | 91 |
| 2022 September | 42 | 27 | 69 |
| 2022 August | 21 | 45 | 66 |
| 2022 July | 27 | 46 | 73 |
| 2022 June | 32 | 43 | 75 |
| 2022 May | 83 | 45 | 128 |
| 2022 April | 125 | 43 | 168 |
| 2022 March | 162 | 60 | 222 |
| 2022 February | 147 | 38 | 185 |
| 2022 January | 151 | 44 | 195 |
| 2021 December | 86 | 47 | 133 |
| 2021 November | 112 | 48 | 160 |
| 2021 October | 65 | 56 | 121 |
| 2021 September | 62 | 54 | 116 |
| 2021 August | 59 | 35 | 94 |
| 2021 July | 48 | 44 | 92 |
| 2021 June | 49 | 29 | 78 |
| 2021 May | 49 | 54 | 103 |
| 2021 April | 141 | 83 | 224 |
| 2021 March | 86 | 28 | 114 |
| 2021 February | 81 | 31 | 112 |
| 2021 January | 59 | 28 | 87 |
| 2020 December | 74 | 15 | 89 |
| 2020 November | 51 | 25 | 76 |
| 2020 October | 62 | 13 | 75 |
| 2020 September | 57 | 22 | 79 |
| 2020 August | 55 | 17 | 72 |
| 2020 July | 52 | 17 | 69 |
| 2020 June | 51 | 31 | 82 |
| 2020 May | 53 | 14 | 67 |
| 2020 April | 53 | 24 | 77 |
| 2020 March | 63 | 15 | 78 |
| 2020 February | 10 | 0 | 10 |
| 2020 January | 4 | 0 | 4 |
| 2019 December | 12 | 2 | 14 |
| 2019 November | 4 | 0 | 4 |
| 2019 October | 1 | 2 | 3 |
| 2019 September | 11 | 2 | 13 |
| 2019 August | 8 | 0 | 8 |
| 2019 July | 4 | 0 | 4 |
| 2019 June | 13 | 0 | 13 |
| 2019 May | 2 | 0 | 2 |
| 2019 April | 13 | 11 | 24 |
| 2019 March | 5 | 0 | 5 |
| 2019 January | 5 | 0 | 5 |
| 2018 December | 10 | 0 | 10 |
| 2018 November | 7 | 0 | 7 |
| 2018 October | 14 | 0 | 14 |
| 2018 September | 8 | 2 | 10 |
| 2018 February | 30 | 3 | 33 |
| 2018 January | 39 | 13 | 52 |
| 2017 December | 42 | 8 | 50 |
| 2017 November | 38 | 10 | 48 |
| 2017 October | 38 | 10 | 48 |
| 2017 September | 36 | 14 | 50 |
| 2017 August | 28 | 6 | 34 |
| 2017 July | 27 | 12 | 39 |
| 2017 June | 32 | 18 | 50 |
| 2017 May | 40 | 14 | 54 |
| 2017 April | 35 | 14 | 49 |
| 2017 March | 28 | 21 | 49 |
| 2017 February | 24 | 17 | 41 |
| 2017 January | 34 | 17 | 51 |
| 2016 December | 29 | 30 | 59 |
| 2016 November | 34 | 28 | 62 |
| 2016 October | 28 | 22 | 50 |
| 2016 September | 0 | 2 | 2 |
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