Correspondence: Servicio de Dermatología, Hospital Universitario de la Princesa. Diego de León, 62. 28006 Madrid. Spain.
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Response to Treatment With Infliximab" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "325" "paginaFinal" => "331" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Pedraz, E. Daudén, S. Pérez-Gala, R. Goiriz-Valdés, P. Fernández-Peñas, A. García-Diez" "autores" => array:6 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Pedraz" "email" => array:1 [ 0 => "javierpedraz@aedv.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Daudén" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Pérez-Gala" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Goiriz-Valdés" ] 4 => array:2 [ "nombre" => "P." "apellidos" => "Fernández-Peñas" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "García-Diez" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Hospital Universitario de la Princesa, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital Universitario de la Princesa. Diego de León, 62. 28006 Madrid. Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hidrosadenitis Supurativa. Respuesta al Tratamiento con Infliximab" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2007-02-08" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec83951" "palabras" => array:3 [ 0 => "tumor necrosis factor" 1 => "hidradenitis suppurativa" 2 => "infliximab" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec83952" "palabras" => array:3 [ 0 => "factor de necrosis tumoral" 1 => "hidrosadenitis supurativa" 2 => "infliximab" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Hidradenitis suppurativa is a chronic inflammatory disease that runs in outbreaks with painful lesions, fistulas and scars in axillae, groins, buttocks, and perianal and submammary regions. Among multiple drug therapies available, infliximab, usually employed in dermatology to control psoriasis, has shown its efficacy in the past five years.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p class="elsevierStyleSimplePara elsevierViewall">It is a prospective, observational study to determine the efficacy and safety of infliximab in the treatment of hidradenitis suppurativa. We selected three women with a history of hidradenitis suppurativa of more than 10 years, with involvement of at least two anatomic locations that was recalcitrant to conventional therapies. Each patient received infliximab at a dose of 5<span class="elsevierStyleHsp" style=""></span>mg/kg/infusion on weeks 0, 2, 6 and every 8 weeks thereafter.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Two of the three patients showed mild to moderate improvement of their disease while the third patient did not improve. We can highlight the variability of the results observed in these three patients. Adverse effects were generally mild and well tolerated by the three patients. Despite this, two patients withdrew the therapy due to loss of efficacy in one case and the development of generalized arthalgias in the other case.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Treatment of hidradenitis supurativa with infliximab constitutes a moderately useful alternative in some cases.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La hidrosadenitis supurativa es una enfermedad inflamatoria crónica, que cursa en brotes, con lesiones dolorosas, fístulas y cicatrices en axilas, ingles, glúteos, región perianal e inframamaria. Entre los múltiples tratamientos farmacológicos disponibles, en los últimos cinco años se ha demostrado la eficacia del infliximab, un tratamiento habitualmente utilizado en dermatología para el control de la psoriasis.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo, observacional, realizado con el objetivo de determinar la eficacia y seguridad del infliximab en el tratamiento de la hidrosadenitis supurativa. Tres pacientes mujeres con hidrosadenitis supurativa de más de 10 años de evolución, con afectación de al menos dos localizaciones anatómicas y resistente a terapias convencionales. Se realiza tratamiento con infliximab a cada una de las pacientes en dosis de 5<span class="elsevierStyleHsp" style=""></span>mg/kg/infusión en las semanas 0, 2, 6 y posteriormente cada 8 semanas.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Dos de las tres pacientes presentaron una mejoría leve-moderada de su enfermedad, mientras que la tercera paciente no obtuvo mejoría. Podemos destacar la variabilidad de los resultados observada entre las tres pacientes. Los efectos secundarios fueron en general leves y bien tolerados por las tres pacientes. Pese a ello, dos de las pacientes tuvieron que suspender el tratamiento debido a la falta de eficacia del mismo en uno de los casos y a un cuadro de artralgias generalizadas en otro.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El tratamiento de la hidrosadenitis supurativa con infliximab constituye una alternativa moderadamente útil en algunos casos.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Terapia biológica y psoriasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Gamo" 1 => "J.L. 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Year/Month | Html | Total | |
---|---|---|---|
2024 October | 61 | 34 | 95 |
2024 September | 74 | 42 | 116 |
2024 August | 106 | 57 | 163 |
2024 July | 68 | 60 | 128 |
2024 June | 90 | 43 | 133 |
2024 May | 59 | 30 | 89 |
2024 April | 59 | 52 | 111 |
2024 March | 61 | 41 | 102 |
2024 February | 48 | 30 | 78 |
2024 January | 38 | 43 | 81 |
2023 December | 44 | 28 | 72 |
2023 November | 46 | 33 | 79 |
2023 October | 38 | 22 | 60 |
2023 September | 45 | 19 | 64 |
2023 August | 31 | 26 | 57 |
2023 July | 32 | 41 | 73 |
2023 June | 43 | 24 | 67 |
2023 May | 26 | 26 | 52 |
2023 April | 35 | 25 | 60 |
2023 March | 23 | 24 | 47 |
2023 February | 33 | 24 | 57 |
2023 January | 50 | 32 | 82 |
2022 December | 48 | 46 | 94 |
2022 November | 29 | 33 | 62 |
2022 October | 23 | 29 | 52 |
2022 September | 25 | 56 | 81 |
2022 August | 29 | 45 | 74 |
2022 July | 18 | 35 | 53 |
2022 June | 23 | 39 | 62 |
2022 May | 36 | 43 | 79 |
2022 April | 56 | 40 | 96 |
2022 March | 40 | 56 | 96 |
2022 February | 54 | 25 | 79 |
2022 January | 30 | 36 | 66 |
2021 December | 30 | 32 | 62 |
2021 November | 48 | 45 | 93 |
2021 October | 48 | 43 | 91 |
2021 September | 46 | 41 | 87 |
2021 August | 45 | 25 | 70 |
2021 July | 42 | 29 | 71 |
2021 June | 44 | 31 | 75 |
2021 May | 38 | 36 | 74 |
2021 April | 90 | 72 | 162 |
2021 March | 64 | 31 | 95 |
2021 February | 62 | 24 | 86 |
2021 January | 42 | 18 | 60 |
2020 December | 47 | 17 | 64 |
2020 November | 26 | 22 | 48 |
2020 October | 37 | 14 | 51 |
2020 September | 40 | 20 | 60 |
2020 August | 38 | 29 | 67 |
2020 July | 40 | 12 | 52 |
2020 June | 50 | 34 | 84 |
2020 May | 73 | 26 | 99 |
2020 April | 41 | 13 | 54 |
2020 March | 41 | 21 | 62 |
2020 February | 7 | 3 | 10 |
2020 January | 1 | 9 | 10 |
2019 December | 0 | 13 | 13 |
2019 November | 0 | 8 | 8 |
2019 October | 0 | 11 | 11 |
2019 September | 0 | 13 | 13 |
2019 August | 0 | 14 | 14 |
2019 July | 0 | 17 | 17 |
2019 June | 0 | 14 | 14 |
2019 May | 0 | 56 | 56 |
2019 April | 0 | 12 | 12 |
2019 March | 0 | 6 | 6 |
2019 February | 0 | 4 | 4 |
2019 January | 0 | 6 | 6 |
2018 December | 0 | 9 | 9 |
2018 August | 0 | 3 | 3 |
2018 July | 0 | 2 | 2 |
2018 June | 0 | 3 | 3 |
2018 May | 0 | 11 | 11 |
2018 March | 0 | 10 | 10 |
2018 February | 10 | 12 | 22 |
2018 January | 21 | 15 | 36 |
2017 December | 26 | 23 | 49 |
2017 November | 29 | 25 | 54 |
2017 October | 19 | 19 | 38 |
2017 September | 27 | 11 | 38 |
2017 August | 45 | 31 | 76 |
2017 July | 44 | 9 | 53 |
2017 June | 38 | 28 | 66 |
2017 May | 58 | 19 | 77 |
2017 April | 51 | 14 | 65 |
2017 March | 38 | 17 | 55 |
2017 February | 34 | 18 | 52 |
2017 January | 39 | 17 | 56 |
2016 December | 52 | 25 | 77 |
2016 November | 39 | 13 | 52 |
2016 October | 43 | 23 | 66 |
2016 September | 45 | 34 | 79 |
2016 August | 59 | 40 | 99 |
2016 July | 51 | 22 | 73 |
2016 June | 13 | 26 | 39 |
2016 May | 4 | 11 | 15 |
2016 April | 9 | 9 | 18 |
2016 March | 5 | 6 | 11 |
2016 February | 9 | 1 | 10 |
2016 January | 6 | 3 | 9 |
2015 December | 8 | 7 | 15 |
2015 November | 15 | 11 | 26 |
2015 October | 9 | 2 | 11 |
2015 September | 5 | 1 | 6 |
2015 August | 11 | 6 | 17 |
2015 July | 18 | 15 | 33 |
2015 June | 21 | 21 | 42 |
2015 May | 53 | 18 | 71 |
2015 April | 31 | 11 | 42 |
2015 March | 25 | 5 | 30 |
2015 February | 17 | 10 | 27 |
2015 January | 23 | 21 | 44 |
2014 December | 19 | 19 | 38 |
2014 November | 14 | 13 | 27 |
2014 October | 23 | 12 | 35 |
2014 September | 28 | 12 | 40 |
2014 August | 40 | 17 | 57 |
2014 July | 53 | 12 | 65 |
2014 June | 34 | 16 | 50 |
2014 May | 35 | 20 | 55 |
2014 April | 45 | 15 | 60 |
2014 March | 40 | 25 | 65 |
2014 February | 15 | 41 | 56 |
2014 January | 29 | 32 | 61 |
2013 December | 37 | 31 | 68 |
2013 November | 28 | 33 | 61 |
2013 October | 23 | 37 | 60 |
2013 September | 32 | 22 | 54 |
2013 August | 15 | 68 | 83 |
2013 July | 40 | 75 | 115 |
2013 June | 26 | 61 | 87 |
2013 May | 29 | 49 | 78 |
2013 April | 33 | 52 | 85 |
2013 March | 32 | 40 | 72 |
2013 February | 39 | 16 | 55 |
2013 January | 20 | 7 | 27 |