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Vol. 109. Num. 9.November 2018
Pages 763-850
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Vol. 109. Num. 9.November 2018
Pages 763-850
Consensus Document
DOI: 10.1016/j.adengl.2018.09.011
Algorithm for Treatment of Chronic Spontaneous Urticaria with Omalizumab
Algoritmo de tratamiento con omalizumab en urticaria crónica espontánea
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J. Spertinoa,
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jspertino@outlook.com

Corresponding author.
, L. Curto Barredob, E. Rozas Muñoza, I. Figueras Nartc, E. Serra Baldricha, M. Bonfill-Ortíc, V. Expósito-Serranod, A. Guilaberte, G. Melé Ninotf, M. Villar Builg, J. Garcias Ladariah, X. García Navarroi, M. Vilavellaj, I. Bielsa Marsolk, G. Aparicio Ortizl, C. Baliu Piquém, A. Álvarez Abellan, N. Lamas Domenecho, J.M. Mascaróp, S. Gómezp, J.I. Torné Gutiérrezq, A. Vicente Villar, A. Gimenez Arnaub
a Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
b Parc de Salut Mar-Hospital del Mar, Barcelona, Spain
c Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain
d Corporació Sanitària Parc Taulí, Sabadell, Barcelona, Spain
e Hospital General de Granollers, Granollers, Barcelona, Spain
f Hospital Universitari Sagrat Cor, Barcelona, Spain
g Hospital de Sant Joan Despí Moisès Broggi, Sant Joan Despí, Barcelona, Spain
h Hospital de Manacor, Manacor, Islas Baleares, Spain
i Consorci Sanitari del Garraf, Sant Pere de Ribes, Barcelona, Spain
j Consorci Sanitari de Terrassa, Terrassa, Barcelona, Spain
k Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
l Hospital Universitari Vall d¿Hebron, Barcelona, Spain
m Consorci Sanitari de l’Anoia, Igualada, Barcelona, Spain
n Hospital Mútua de Terrassa, Terrassa, Barcelona, Spain
o Hospital Dos de Maig, Barcelona, Spain
p Hospital Clínic de Barcelona, Barcelona, Spain
q Hospital Sant Llàtzer, Terrassa, Barcelona, Spain
r Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain
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Actas Dermosifiliogr.2018;109:76610.1016/j.adengl.2018.10.001
R. Ruiz-Villaverde
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Abstract
Background and objective

Pivotal trials with omalizumab for treatment of chronic spontaneous urticaria (CSU) are generally run over 12 to 24weeks. However, in clinical practice, many patients need longer treatment. In this article, we present an algorithm for treatment with omalizumab.

Material and methods

The consensus document we present is the result of a series of meetings by the CSU working group of “Xarxa d’Urticària Catalana i Balear” (XUrCB) at which data from the recent literature were presented, discussed, compared, and agreed upon.

Results

Treatment with omalizumab should be initiated at the authorized dose, and is adjusted at 3-monthly intervals according to the Urticaria Activity Score Over 7days, the Urticaria Control Test, or both.

Conclusions

The algorithm proposed is designed to provide guidance on how to adjust omalizumab doses, how and when to discontinue the drug, and how to reintroduce it in cases of relapse.

Keywords:
Omalizumab
Chronic spontaneous urticaria
Treatment algorithm
Resumen
Antecedentes y objetivo

Los ensayos pivotales de omalizumab en urticaria crónica espontánea (UCE) tienen un periodo de tratamiento de entre 12 y 24semanas. Sin embargo, muchos pacientes en práctica clínica requieren periodos de tratamiento más prolongados. Por ello el objetivo es presentar un algoritmo de manejo del fármaco.

Materiales y métodos

El documento de consenso que detallamos nace de la puesta en común, aceptación, revisión y confrontación de la literatura reciente del grupo de trabajo de UCE «Xarxa d’Urticària Catalana i Balear» (XUrCB).

Resultados

Se inicia el tratamiento a dosis autorizada y se ajusta la dosis en intervalos trimestrales en función del Urticaria Activity Score de los últimos 7días (UAS7) y/o el Urticarial Control Test (UCT).

Conclusiones

El algoritmo propuesto pretende servir de guía respecto a cómo ajustar dosis, cómo y cuándo parar el fármaco y el modo de reintroducirlo en casos de recaída.

Palabras clave:
Omalizumab
Urticaria crónica espontánea
Algoritmo de tratamiento

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